Clinical features of Barré-Lièou syndrome and efficacy of trazodone for its treatment: A retrospective single center study

Barre-Lieou syndrome (BLS) is a manifestation of various autonomic and secondary symptoms including muscle stiffness, tinnitus, dizziness, pain in body parts. Although considered to be caused by hyperactivation the nervous system due trauma, there currently no firmly established etiology or evidence on treatment clinical features BLS. We retrospectively examined BLS evaluated efficacy trazodone (TZD) for its treatment. conducted retrospective analysis data 20 consecutive cases with suspected who were treated our hospital between 2016 2019. rated 10-point scale, two groups defined, that is, mild-BLS group (BLS scores, 1-5) severe-BLS 6-10). Univariate patient factors was performed. The score 6.0 ± 1.7, maximum TZD dose 80 34 mg/day; nine patients (45%) free, side effects observed, while all had good outcome. There significant differences period from injury diagnosis (p = 0.015), chest/back < 0.001), constipation 0.008). involves posttraumatic accompanied depression insomnia. sympathetic hypersensitivity theory could explain etiology. effectively safely treat BLS, early can contribute toward outcomes. Enhanced recognition understanding this disease are warranted.